Verordnungspraxis und Risiken von Protonenpumpenblockern – Fiktion und Fakten

Zusammenfassung

Derzeit werden ein nicht-indikationsgerechter Einsatz und potenzielle Risiken einer Therapie mit Protonenpumpeninhibitoren (PPI) intensiv diskutiert. Diese Übersichtsarbeit beleuchtet kritisch das Verschreibungsverhalten bzgl. PPI in Praxis und Klinik, zeigt Exit-Strategien aus einer langfristigen PPI-Behandlung auf und evaluiert kritisch das Risikoprofil von PPI.

Abstract

There is substantial discussion about inappropriate prescriptions and risks of proton pump inhibitor (PPI) therapy. This review critically reviews prescription manners regarding PPI both by general practitioners and in hospitals, demonstrates exit strategies after prolonged PPI treatment and evaluates clinically relevant risks of PPI therapy.

Schlüsselwörter

Protonenpumpeninhibitoren - Therapie - Pneumonie - Knochenfrakturen - Niereninsuffizienz - gastrointestinale Infektion - Malabsorption

Key words

proton pump inhibitors - therapy - pneumonia - bone fractures - renal insufficiency - enteric infections - malabsorption

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